I recently had a blood test because my doctor suspects that I have celiac disease. The results, in her words, suggest that I carry the antibody for celiac disease: The ANA screen is negative (no titer performed), the tTG-IgA is negative (<1.2U/mL), but the tTG-IgG is positive (10.5 U/mL).
My doctor did not recommend further testing, such as a biopsy, to confirm the celiac diagnosis, but did recommend that I eat completely gluten-free and see a dermatologist to diagnose the rash that I have, that seems to be consistent with pictures and descriptions of dermatitis herpetiformis. I am seeing another doctor to manage my new diet, and she thinks that the positive tTG-IgG test, along with the other symptoms I have described (skin rash and some GI issues) are conclusive enough that I shouldn’t go to the expense and trauma of a biopsy.
Am I wrong to not pursue further testing? Do other diseases closely mimic celiac? And I’ve read that the IgG test is less specific than the IgA test for diagnosing celiac – has anyone else had a negative IgA test and positive IgG test and found that they do have celiac disease? Thanks in advance for your comments.



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